Weight & Metabolic
GLP-1 and related compounds appearing in weight management and metabolic research, summarized for educational context.
Retatrutide
A triple agonist of the GLP-1, GIP, and glucagon receptors, studied for appetite control, energy use, and substantial weight-loss research.
What to expect: Appetite usually drops, portions get smaller, and weight can come off steadily over a cycle as the dose is increased, with possible nausea or stomach upset during the first weeks.
Tirzepatide
A dual GIP and GLP-1 receptor agonist studied in clinical research for its effects on appetite signaling, glycemic control, and weight management.
What to expect: Hunger usually fades, portions get smaller, and weight comes off slowly over weeks, with some people getting mild nausea when the dose increases.
GHRP-6
A GH-releasing peptide known for a strong hunger signal along with the GH pulse.
What to expect: Appetite can jump fast after a dose. Sleep and recovery may improve, but hunger is the first thing most people notice.
HGH-191AA
Recombinant somatropin, the intact growth hormone used in approved deficiency treatment and studied for body composition.
What to expect: Sleep, recovery, and lean mass can improve more clearly than with secretagogues, with more water retention and acne risk.
Semaglutide
A long-acting GLP-1 receptor agonist studied for appetite control, blood sugar regulation, and weight-loss research.
What to expect: Hunger usually fades, meals get smaller, and weight comes off gradually over months, with nausea or stomach upset most common while the dose is going up.
Cagrilintide
A long-acting amylin analogue investigated in clinical research for appetite regulation and weight management, often studied alongside GLP-1 agonists.
What to expect: Meals feel satisfying sooner, snacking drops, and weight loss is gradual, with possible mild nausea while your stomach adjusts.
GHRP-2
A GH-releasing peptide that raises growth hormone pulses and often hunger.
What to expect: Sleep and recovery can improve, with a clear appetite bump after the shot. Hunger is stronger than with ipamorelin.
Tesamorelin
A growth hormone releasing hormone analogue studied for visceral fat reduction, GH signaling, and body-composition research.
What to expect: Midsection fat may drop gradually as GH rises, with better sleep and recovery and some water retention.
MOTS-c
A mitochondrial peptide studied for metabolic flexibility, exercise-related signaling, and energy use.
What to expect: Workouts and all-day energy can feel a bit more efficient, with modest body-composition support over time.
AOD-9604
A modified HGH fragment studied for fat-metabolism research without the full growth effects of intact HGH.
What to expect: Appetite and scale changes are usually mild. Think slight help with fat use, not a GLP-level drop.
Retatrutide
A triple agonist of the GLP-1, GIP, and glucagon receptors, studied for appetite control, energy use, and substantial weight-loss research.
What to expect: Appetite usually drops, portions get smaller, and weight can come off steadily over a cycle as the dose is increased, with possible nausea or stomach upset during the first weeks.
GHRP-6
A GH-releasing peptide known for a strong hunger signal along with the GH pulse.
What to expect: Appetite can jump fast after a dose. Sleep and recovery may improve, but hunger is the first thing most people notice.
Semaglutide
A long-acting GLP-1 receptor agonist studied for appetite control, blood sugar regulation, and weight-loss research.
What to expect: Hunger usually fades, meals get smaller, and weight comes off gradually over months, with nausea or stomach upset most common while the dose is going up.
GHRP-2
A GH-releasing peptide that raises growth hormone pulses and often hunger.
What to expect: Sleep and recovery can improve, with a clear appetite bump after the shot. Hunger is stronger than with ipamorelin.
MOTS-c
A mitochondrial peptide studied for metabolic flexibility, exercise-related signaling, and energy use.
What to expect: Workouts and all-day energy can feel a bit more efficient, with modest body-composition support over time.
Tirzepatide
A dual GIP and GLP-1 receptor agonist studied in clinical research for its effects on appetite signaling, glycemic control, and weight management.
What to expect: Hunger usually fades, portions get smaller, and weight comes off slowly over weeks, with some people getting mild nausea when the dose increases.
HGH-191AA
Recombinant somatropin, the intact growth hormone used in approved deficiency treatment and studied for body composition.
What to expect: Sleep, recovery, and lean mass can improve more clearly than with secretagogues, with more water retention and acne risk.
Cagrilintide
A long-acting amylin analogue investigated in clinical research for appetite regulation and weight management, often studied alongside GLP-1 agonists.
What to expect: Meals feel satisfying sooner, snacking drops, and weight loss is gradual, with possible mild nausea while your stomach adjusts.
Tesamorelin
A growth hormone releasing hormone analogue studied for visceral fat reduction, GH signaling, and body-composition research.
What to expect: Midsection fat may drop gradually as GH rises, with better sleep and recovery and some water retention.
AOD-9604
A modified HGH fragment studied for fat-metabolism research without the full growth effects of intact HGH.
What to expect: Appetite and scale changes are usually mild. Think slight help with fat use, not a GLP-level drop.
