Peptide GuideCagrilintide

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Cagrilintide

AppetiteWeight

Cagrilintide is a long-acting amylin analogue under clinical investigation for appetite regulation and weight management, including research alongside GLP-1 therapies.

What does it do?

Makes you feel full faster during a meal
Helps fullness last longer after you eat
Reduces the urge to keep eating
Supports gradual weight loss through appetite control
Pairs well with GLP-1 medicines in research stacks
Can cause nausea while the body adjusts

How does it work?

Mimics amylin, a hormone released with insulin after meals
Tells the brain that you have eaten enough
Slows how quickly food leaves the stomach
Works on satiety more than on stimulation or energy
Complements GLP-1 drugs because it hits a different fullness pathway
The result is earlier satisfaction, not a wired or stimulant feeling

What to expect?

You get full faster and stay full longer after a normal meal
The urge to keep eating fades earlier in the plate
Nausea can show up while you adjust, especially at first
Weight change is real but usually slower than tirzepatide
It feels like appetite control and early fullness, not like a stimulant

How it's typically administered

Sub-Q injectionSubcutaneous injectiononce weekly in clinical trials; combination pens are under study

How it's typically dosed

Most common dose0.3–2.4 mg
FrequencyOnce weekly
Cycle durationTitrated upward

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