Cagrilintide
AppetiteWeight
Cagrilintide is a long-acting amylin analogue under clinical investigation for appetite regulation and weight management, including research alongside GLP-1 therapies.
What does it do?
- Reduces appetite and food intake by mimicking the satiety hormone amylin
- Supports weight loss, especially when combined with GLP-1 therapies
How does it work?
- Long-acting amylin receptor agonist
- Slows gastric emptying and enhances satiety signaling
How it's typically administered
- Subcutaneous injectiononce weekly in clinical trials
- Combination pensstudied together with semaglutide
- Topical serum or creamnot effective systemically
- Nasal sprayunreliable absorption; little research support
- Oral capsulesnot bioavailable orally
- Intramuscular injectionunnecessary and higher risk
How it's typically dosed
- Most common dose0.3–2.4 mg
- FrequencyOnce weekly
- Cycle durationTitrated upward