Peptide GuideVIP

The Peptide Guide

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VIP

Lung supportSleep quality

VIP (vasoactive intestinal peptide) is a 28-amino-acid signaling peptide used for airway comfort, circulation, and inflammatory balance. Nasal use is common.

What does it do?

Activates VPAC receptors and raises cAMP in airway and vessel tissue
Relaxes smooth muscle in the lungs and vasculature
Helps shift inflammatory signaling toward a calmer pattern
Can ease breathing or sleep rhythm
Short-lived in blood, so doses are split
Flushing comes from the same vessel-relaxing action

How does it work?

Hits VPAC receptors and raises cAMP in target tissue
Relaxes smooth muscle in airways and vessels
Helps shift inflammatory signaling
Half-life in blood is very short, so nasal or split dosing is used
Not a rescue inhaler
Clinic nasal protocols often start low because blood pressure can dip

What to expect?

Flush or a stuffy nose can follow a dose
The first nasal sprays can drop blood pressure a little
Breathing can feel a bit easier later, not instantly
Sleep rhythm can settle for some users
The feeling is warmth and air, not focus

How it's typically administered

Nasal sprayNasal spraymost common
Sub-Q injectionSubcutaneous injectionused in research settings

How it's typically dosed

Most common dose50 mcg per spray
FrequencyStart 1–2x daily, then increase
Cycle durationWeeks to months

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