Peptide GuideARA-290

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ARA-290

HealingNerve comfort

ARA-290 (cibinetide) is an 11-amino-acid peptide taken from erythropoietin. It was studied for small-fiber neuropathy and tissue protection without raising red blood cells.

What does it do?

Activates a tissue-repair receptor derived from EPO without raising red blood cells
Supports small-fiber nerve comfort in neuropathy research
Helps lower inflammatory signaling around irritated nerves
Used for nerve and tissue protection, not muscle growth
Does not act like EPO on hematocrit
Benefits accumulate over weeks rather than after one dose

How does it work?

Activates the innate repair receptor instead of the classic EPO receptor
Sends tissue-protection signals without boosting red cell production
Helps quiet inflammatory signaling around nerves
Has been studied at milligram doses in short human trials
Works as a repair peptide, not a stimulant or opioid
Effects are measured over weeks, not hours

What to expect?

The first two weeks often feel like nothing
Nerve irritation, if it eases, does so later in the cycle
Injection sites are usually quiet
It does not numb pain the way a painkiller does
The shift is a lower background ache, not a switch flipping off

How it's typically administered

Sub-Q injectionSubcutaneous injectionthe route used in trials
OralOralnot used in published work

How it's typically dosed

Most common dose2–4 mg
FrequencyOnce daily
Cycle duration4 weeks

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